Loss of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity

P-cadherin is a major contributor to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes and in maintaining tissue integrity and homeostasis. Alterations of P-cadherin expression have been observed during the progression of several carcinomas where it appears to act as tumor suppressive or oncogenic in a contextdependent manner The aim of this study was to assess P-cadherin expression and its role in hepatocellular carcinoma (HCC). Material and methods: Quantitative PCR analysis revealed a significant downregulation of P-cadherin mRNA in 4 huma…