Antidromic NFATc1 and p53 signaling at the edge of differentiation and stemness in pancreatic cancer
SK Singh, S Vogt, N Völker, B Geisel, NM Chen, E Glesel, K Reutlinger, G Singh, S Baumgart, TM Gress, V Ellenrieder · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: The current concept suggests a direct link between EMT and stemness induction in pancreatic cancer, thereby coupling cell motility and de-differentiation with self-renewal capacities and drug resistance. Both key features of cellular plasticity are controlled by distinct intracellular signaling and transcription pathways. We have shown that activation of the NFATc1 transcription factor promotes pancreatic cancer development and metastasis through its ability to integrate extrinsic stimuli into coordinated gene regulation. Aim: To assess whether NFATc1 controls transcription of EMT genes and stemnes…
