The Temperature Rise by Acoustic Radiation Force Impulse under administration of Sonazoid™ (Perfluorobutane): Preliminary Study

The Acoustic Radiation Force Impulse (ARFI) is recently used to evaluate tissue elasticity in some organ. When the biological tissue is exposed by ARFI, the damage by greater ultrasonic pulse and combination with contrast agents is still unknown in both mechanical and thermal effects. Thus, concurrent administration of contrast agent for ultrasound imaging with ARFI had not been advocated, the heat and/or cavitation may occur. Purpose: The thermal effect of ARFI on the living animal tissue is evaluated with or without contrast material, Sonazoid™ (perfluorobutane). Material and method: The rabbit (Japan white, B…