Molecular mechanisms of EGFR activation by carbon nanoparticles in lung epithelial cells
D Stöckmann, H Peuschel, U Sydlik, M Kroker, N Ale-Agha, S Jakob, J Haendeler, S Grether-Beck, K Unfried · Pneumologie · 2013 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background: Particulate air pollution induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions in lung epithelial cells. The activation of the epidermal growth factor receptor (EGFR) is a key step responsible for signaling events specific for these endpoints. Earlier experiments identified particle-derived reactive oxygen species (ROS) as one possible trigger eliciting the observed EGFR activation. As initial molecular mechanism responsible for the activation of this signaling event, we hypothesize a ligand-independent internalization of EGFR involving caveolin-1. Methods: Membr…
