Avidity and shear stress-linked anchoring to tumor endothelium: transfer the principles of leukocyte adhesion for tumor-specific drug delivery

Avidity and shear stress-linked anchoring to tumor endothelium: transfer the principles of leukocyte adhesion for tumor-specific drug delivery Site-specific leukocyte adhesion to endothelium is usually controlled by two factors: by increase of molecule avidity and by hydrodynamic shear force. In the present project, we tested these principles for specific anchoring of tumor endothelial cells (TEC) in HCC. First, we analysed the cell surface expression changes of various endothelial markers in murine/human HCC and liver tissue in the process of tumor vessel capillarization using immunofluorescence. We identified…