CareLit Fachartikel

Human keratin 8 variants predispose to acetaminophen hepatotoxicity

N Guldiken, Q Zhou, O Kucukoglu, M Rehm, LP James, C Trautwein, MB Omary, P Strnad · Zeitschrift für Gastroenterologie · 2014 · Heft 01

Dokument
1173440
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
N Guldiken, Q Zhou, O Kucukoglu, M Rehm, LP James, C Trautwein, MB Omary, P Strnad
Ausgabe
Heft 01 / 2014
Seiten
–
Erschienen: 2014-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1360899

Zusammenfassung

Keratins 8 and 18 (K8/K18) are the intermediate filaments of digestive epithelia and display an important hepatoprotective function. Accordingly, K8/K18 variants predispose humans to chronic liver disease and to acetaminophen toxicity. Given that K8 G62C and K8 R341 H/C are abundant K8 variants in European population, we studied their importance using newly generated/previously described mice subjected to acetaminophen (APAP) overdose. Under basal conditions, K8 G62C/K8 R341 C/H mice did not show any obvious liver phenotype or altered keratin distribution pattern. 18 hours after APAP administration (600 mg/kg),…

Schlagworte

Acetaminophen After Population Cytokine Zeitschrift für Gastroenterologie