Reduction of alkaline phosphatase levels improves survival in PSC patients independent of dominant stenosis
C Rupp, A Rößler, K Friedrich, A Wannhoff, KH Weiss, P Sauer, W Stremmel, DN Gotthardt · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: Alkaline phosphatase (AP) is an important serum marker in primary sclerosing cholangitis (PSC). Patients with biliary obstructions of the large bile ducts due to dominant strictures resemble a special, clinically important phenotype. We aimed to assess the value of AP in predicting outcome depending on the presence of dominant strictures. Patients and methods: This is a prospective cohort study of 218 PSC patients that were treated with UDCA and endoscopic interventions over the period 1987 – 2012 in our tertiary care center. Laboratory values were examined in at least yearly intervals. Result…
