Offspring of high fat diet fed dams develop hepatic steatosis

Introduction: Overweight and associated comorbidities are on the rise, in particular in industrialized societies. Moreover, overweight among adolescents and young adults are increasing dramatically. It is still unclear to what extent alimentation of the mothers during pregnancy may affect this trend via fetal programming. Methods: Female C57BL/6 mice were fed a high fat diet (HFD) starting 6 weeks prior mating. The offspring (HFK) of these HFD fed dams were weaned to standard diet at 21 days of age and were sacrificed to collect serum, liver and adipose tissue at 6, 14, or 26 weeks postpartum, respectively. Intr…