Nup155 is linked to the p53 pathway in HCC
K Holzer, A Ori, J Winkler, E Eiteneuer, K Breuhahn, M Beck, P Schirmacher, S Singer · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Virtually all signaling cascades of (liver-)cancer relevant pathways have to pass the nuclear pore complex (NPC) as the only gate between the cytoplasm and the nucleus. The NPC is embedded in the nuclear envelope and consists of approximately 30 different nucleoporins (Nups). We could previously show that Nup98 is linked to the p53 pathway by preventing a subset of p53 target gene-mRNAs from exosomal degradation. Nup98 emerged from a Nup-siRNA screen that indicated pleiotropic effects of a variety of Nups on p53 target gene induction. Here, we investigated the role of Nup155 (that was not included in the aforeme…
