Wnt-signaling gradients and their impact on liver parenchymal heterogeneity – a link to xenobiotic metabolism
J Böttger, K Günter, S Aleithe, M Matz-Soja, E Marbach, U Hofmann, R Gebhardt · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
The functional heterogeneity and plasticity of the liver parenchyma is known as metabolic zonation. Beside this the morphogen signaling takes a special position to control the homeostasis of metabolic zonation along the porto-central axis in the liver lobuli. Wnt factors are of particular importance, since the Wnt signaling has been identified as the main determinant of liver parenchyma zonation. For instance, the deletion of APC leads to an activation of the wnt signaling pathway in the pericentral area of the lobuli and thus resulting in a shift of the balance between anabolic and catabolic functions. However,…
