The role of CCR2+ CD4 T cells in lung fibrosis
K Milger, Y Yu, E Brudy, M Irmler, A Skapenko, M Mayinger, M Königshoff, O Eickelberg, S Krauss-Etschmann · Pneumologie · 2014 · Heft 02
Bibliografische Angaben
Zusammenfassung
Introduction: T cells have been suggested to play important roles in the development of lung fibrosis. Chemokine receptor 2 (CCR2), the receptor of macrophage chemoattractant protein-1 (MCP-1), is expressed by many immune cell types including T cells. The broad inhibition of CCR2-dependent signaling was shown to attenuate the development of pulmonary fibrosis in animal models. However, the specific role of CCR2+CD4+ T cells in pulmonary fibrosis is unknown. Objectives: To investigate the phenotype and function of CCR2+CD4+ T cells using the bleomycin-induced lung fibrosis model and BALF samples from patients wit…
