An adaptive strategy for detection of high-frequency oscillations in surface EEG/MEG recordings in an epilepsy patient

Introduction: High frequency oscillations (HFOs) have recently received attention as possible biomarkers for epileptic activity in both intracranial as well as surface recordings. HFOs have been used to investigate the epileptogenicity of individual brain regions and a predictive role of HFOs with respect to the clinical outcome of resective surgery has been postulated. While some of the studies published to date rely on the occurence of spikes in intracranial recordings as triggers for time-locked averaging of EEG or MEG to reveal HFOs, the present study assessed whether HFOs can be detected in surface EEG and…