Functional resting-state connectivity of the human motor network: Differences between right- and left-handers

Background: Handedness, i.e., the preference to use one hand over the other, has been shown to be associated with differences in activation levels in various motor tasks performed with the dominant or non-dominant hand (Gilbert & Wysocki, 1992; White et al., 1994). We were interested whether also in the absence of an overt motor task, i.e., during “resting-state”, spontaneous fluctuations of primary motor cortex activity shows differential functional connectivity in the left or right hemisphere depending on whether subjects report left- or right-handedness. Methods: We, therefore, scanned 24 volunteers (12 right…