Characterization of precursor lesions and tumor heterogeneity in murine endogenous pancreatic adenocarcinoma by 18F-FDG PET
I Heid, C Wörner, K Steiger, M Trajkovic-Arsic, M Schwaiger, I Esposito, JT Siveke, R Braren · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2014 · Heft 04
Bibliografische Angaben
Zusammenfassung
Zielsetzung: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease due to a late and difficult diagnosis. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) has been widely used for the diagnosis and staging of PDAC. Genetically engineered mouse models (GEMM) are well-established tools for preventive and preclinical studies in PDAC. A detailed characterization of these models via PET is lacking. Therefore, the goal of this study was to characterize the FDG tracer uptake in different GEMM of PDAC. Material und Methodik: Ptf1awt/Cre(C)Kraswt/LSL-G12D(K)Ela-Tgfa(T), CK;p53(P)wt/fl, CKPfl/fl,…