Regulating the activity of p38α/β as a potential therapy against childhood acute lymphoblastic leukemia
A Alsadeq, S Strube, S Krause, M Carlet, I Jeremias, C Vokuhl, S Loges, JA Aguirre-Ghiso, G Cario, M Stanulla, M Schrappe, DM Schewe · Klinische Pädiatrie · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and 15% of the treated patients suffer from relapse. Understanding the biological factors that enhance or inhibit ALL cell proliferation can help in improving the current therapies. During normal hematopoiesis, the MAPK family member p38 mediates growth-inhibitory signals. In this study we have further investigated the role of p38 in ALL biology in vitro and in vivo and found that it plays a pivotal role in ALL proliferation. The growth-kinetics of several ALL cell lines were measured and were correlated with the phosphorylation levels of…
