A caspase gene-based security mechanism for potential leukemogenesis in human cord blood-derived T cell progenitors
J Hübner, S Hoseini, M Hapke, J Herbst, J Sürth, H Maul, A Schambach, M Brenner, M vd Brink, M Sauer · Klinische Pädiatrie · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
* these authors contributed equally. Co-transplantation of genetically engineered T cell precursors together with hematopoietic stem cells is a promising means of specifically target tumor-associated antigens but avoid non specific alloreactivity causing graft versus host disease complicating the adoptive transfer of allogeneic mature T cells. However, genetic modification of undifferentiated precursor cells bears the risk of insertional mutagenesis and off-target-toxicity. Novel safety mechanisms to control activity of genetically engineered cells would ease its transfer into clinical practice. Here, we have mo…
