The influence of thyroid dysfunction on the activity of brown adipose tissue in mice detected by [18F]FDG PET/MR
K Krause, M Kranz, V Zeisig, N Klöting, K Steinhoff, W Deuther-Conrad, M Fasshauer, M Stumvoll, O Sabri, S Hesse, P Brust, A Tönjes · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Thyroid hormones exert direct effects on metabolically active tissues, such as brown adipose tissue (BAT) (Bianco et al. 2005). Recently, it has been shown that thyroid status affects BAT activity in human (Skarulis et al. 2010). The aim of this study was to investigate how thyroid dysfunction (hyper- and hypothyroidism) affects (a) BAT activation and (b) gene expression in subcutaneous, visceral and BAT in C57BL/6 mice. Hyperthyroidism was induced by application of L-thyroxine daily (2 µg/ml diluted in drinking water). Hypothyroidism was generated by application of an iodine deficient diet containing 0.15% prop…
