A role for the novel cytokine wnt-5a in linking inflammation to metabolism in human sepsis
DM Schulte, D Kragelund, N Müller, G Elke, A Titz, D Schädler, K Neumann, J Schumacher, N Weiler, B Bewig, S Schreiber, M Laudes · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Sepsis (hot inflammation) and type 2 diabetes mellitus (T2DM; cold low-grade metabolic inflammation) exhibit insulin resistance as a common phenotype. In T2DM, we have shown before that the wnt-5a/sFRP-5 system is crucial in the development of insulin resistance. The aim of the present study was to investigate whether pro-inflammatory wnt-5a and its specific inhibitor sFRP-5 are also potential mediators between inflammation and metabolism in human sepsis. In this mono-centre prospective observational study, critically ill human subjects suffering from sepsis were included and wnt-5a and sFRP-5 were measured at a…
