Metabolic footprint of the GLP-1 receptor agonist liraglutide in adolescent transgenic pigs with impaired incretin function
S Renner, E Streckel, C Braun-Reichhart, W Römisch-Margl, C Prehn, J Adamski, E Wolf · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aim: Metabolites can be very sensitive markers for the evaluation of drug efficiency and safety. We analyzed changes in the metabolome of adolescent pre-diabetic pigs expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) after treatment with the GLP-1 receptor agonist liraglutide using a targeted metabolomics approach. Methods: 2-month-old GIPRdn transgenic pigs were treated with 0.6 mg – 1.8 mg liraglutide or placebo once daily for 90 days. Plasma samples from mixed meal oral glucose tolerance tests performed after 90 days of treatment (4 measurements) were chosen for met…
