CareLit Fachartikel
Human T-Lymphocytes are affected by notch ligands in vitro
T Zoeggeler, K Watzinger, C Kaehler · Pneumologie · 2014 · Heft 05
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1174227
CareLit-ID
Jahr
2014
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Zusammenfassung
Notch signaling is believed to be engaged in the pathophysiology of lung cancer and PAH. More recently, a significant increase of the perivascular number of T cells, cytotoxic T cells (CD8) and helper T cells (CD4) in vessels of IPAH lungs was shown. The aim of this study was to uncover, which influence the Notch-signaling pathway has on the migratory behaviour of human T-cells, in vitro. T-cells were isolated from EDTA-anticoagulated venous blood, taken from healthy donors. The isolation was carried out according to a standardized MACS protocol. For chemotaxis experiments, a microchemotaxis chamber was used. Fr…
Schlagworte
Atmosphere
Chemotaxis
Cellulose
Blood
ADAM-17
After
Pneumologie
