CareLit Fachartikel
Interaction between IL23R gene and IBD5 locus in Hungarian ulcerative colitis patients
P Sarlós, L Nagy, V Csöngei, L Magyari, B Melegh · Zeitschrift für Gastroenterologie · 2014 · Heft 05
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1174236
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2014
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In previous single-locus association studies, the IBD5 loci were found not to confer susceptibility to UC, while the rs2201841 and rs1004819 IL23R were not investigated in Hungarian UC patients. The aim of our current work was to study two IL23R SNPs (rs1004819 and rs2201841) in Hungarian UC population and to test for possible statistical interaction, stratifying the IL23R genotypes by IBD5 genotypes. 320 unrelated subjects with ulcerative colitis and 316 healthy controls were genotyped. Interactions and specific genotype combinations of a total of seven variants were tested. The variants of IBD5 locus (IGR2198a…
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Zeitschrift für Gastroenterologie
