Regulation of autophagy in pulmonary fibrosis

Importance of lysosome related pathways under conditions of idiopathic pulmonary fibrosis is not extensively studied till date. Autophagy has been known from several years as a self-eating catabolic pathway, activated mainly to degrade the cell's own unused organelles, macromolecules and long-lived proteins via the lysosomal system. Here, we aimed to study the regulation of autophagy in idiopathic pulmonary fibrosis as well as in murine model of bleomycin induced lung fibrosis. Markers of different forms of autophagy were analyzed in the lungs of IPF patients, healthy donors and vehicle or bleomycin treated mice…