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Do B-cells contribute to experimental Bronchiolitis obliterans syndrome?

M Reichert, S Atanasova, G Fuchs-Moll, K Petri, W Padberg, V Grau · Pneumologie · 2014 · Heft 06

Dokument
1174260
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Reichert, S Atanasova, G Fuchs-Moll, K Petri, W Padberg, V Grau
Ausgabe
Heft 06 / 2014
Seiten
–
Erschienen: 2014-06-10 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0034-1376819

Zusammenfassung

Objectives: Recently, we established a clinically relevant experimental model for human bronchiolitis obliterans syndrome (BOS), which involves orthotopic transplantation of rat lung allografts followed by intratracheal application of lipopolysaccharide (LPS) (Atanasova et al. 2013, J Heart Lung Transplant 32: 1131). Chronic lung damage does neither develop in allografts treated with vehicle instead of LPS nor in pulmonary isografts. Alloreactive and autoreactive antibodies have been detected in BOS patients but their pathogenic role is disputed. Here, we investigate B cell infiltration into experimental lung al…

Schlagworte

Allografts Transplantation Antibodies After Bronchiolitis Obliterans Bronchiolitis Blood Vessels Blood Pneumologie