Metabolic biomarkers to differentiate pancreatic ductal adenocarcinoma and chronic pancreatitis
J Mayerle, H Kalthoff, R Reszka, B Kamlage, E Peter, B Schniewind, S González Maldonado, V Liebenberg, C Pilarsky, P Schatz, JA Scheiber, FU Weiss, R Grützmann, MM Lerch · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Current non-invasive diagnostic tests can distinguish between pancreatic cancer (PDAC) and chronic pancreatitis (CP) in only about two thirds of patients. Objectives: To identify a panel of plasma metabolite biomarkers for this diagnostic purpose. Methods: For a case-control study in three tertiary referral centres 914 subjects were prospectively recruited with either pancreatic cancer (n = 271), chronic pancreatitis (n = 282), liver cirrhosis (n = 100), or healthy as well as non-pancreatic disease controls (n = 261). An initial exploratory study (n = 201) was followed by a multicentre training study…
