CareLit Fachartikel
Granulocyte colony stimulating factor (G-CSF) to treat acute (on chronic) liver failure: effect on immune and stem cell mobilisation
C Engelmann, K Splith, T Berg, M Schmelzle · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Dokument
1174511
CareLit-ID
Jahr
2014
Publikation
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Metadaten
DOI
ja
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Bibliografische Angaben
Zusammenfassung
Background and aims: Granulocyte stimulating factor (G-CSF) is a potential new treatment option for patients with severe acute (on-chronic) liver failure that mobilises hematopoetic stem cells (CD34+) and improves patients' outcome. But until now its mechanism of action leading to an improvement of liver regeneration could not have been clarified. In this investigation the impact of immune- and stem-cell mobilisation into the blood on patients' outcome was evaluated. Methods: Filgrastim was administered as an individualised treatment with 12 subcutaneous doses (5 µg/kg day 1 – 5 daily, day 6 – 26 every third day…
Schlagworte
Acute-On-Chronic Liver Failure
Blood
Creatinine
Bilirubin
Hepatitis
Zeitschrift für Gastroenterologie
