Common procholestatic variants may confer risk of anabolic steroids induced cholestasis: presentation of two cases
M Krawczyk, J Raszeja-Wyszomirska, M Wasilewicz, A Bohner, M Krawczyk, P Milkiewicz, F Lammert · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Use of anabolic steroids (AAS) increases among amateur athletes. Over 96% of AAS users report side effects (Bolding/Elford, Addiction 2002), including acute cholestasis. We present two patients carrying procholestatic polymorphisms within hepatobiliary transporter genes (bile salt export pump ABCB11, phosphatidylserine flippase ATP8B1 and phosphatidylcholine floppase ABCB4) who developed cholestasis after use of AAS. Methods and results: Two male patients (age 24 and 26 years) were admitted to our department with acute AAS-induced cholestasis. Laboratory tests revealed increased serum bilirubin level…
