TRK-antagonist inhibits PanIN progression and cancer in an inflammatory PDAC mouse model
BW Renz, CB Westphalen, Y Hayakawa, A Kleepies, J Werner, H Remotti, KP Olive, TC Wang · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Activation of nerve growth factor neurotrophic tyrosine kinase receptor signaling leads to enhanced proliferation of pancreatic cancer (PDAC) cells. Aim: The aim of this study was to investigate the effect of an experimental pan-TRK receptor tyrosine kinase inhibitor on proliferation of human and murine PDAC cells in vitro and on the progression of PanIN lesions and cancer in the PDX-Cre/LSL-KRASG12D (KC) mouse model. Methods: Four human (AsPC-1, BxPC-3, MiaPaCa-2, Panc-1) and two murine (K2548 and K8282) PDAC cell lines were investigated. After determining the expression of TRK-receptors by qPCR a…
