The G-Protein Coupled Estrogen Receptor (GPER/GPR30) in ovarian granulosa cell tumors

Introduction: Ovarian granulosa cell tumors (GCTs) comprise a rare entity of ovarian sex cord stroma tumors. In line with their putative cells of origin GCTs possess the ability to synthesize estrogen and are supposed to be responsive to gonadotropins (FSH/LH). We recently identified the G-protein coupled estrogen receptor (GPER/GPR30) to be regulated by LH and FSH and to be differentially expressed throughout ovarian follicle development. Thus, supposing a possible role of GPER in GCTs, this study aimed to analyze GPER in GCTs and whether GPER might be correlated with clinicopathological parameters. Methods: FF…