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Increased Lysyl oxidase-like 2 (LOXL2) gene expression accurately designates advanced liver fibrosis induced by the Hepatitis C Virus (HCV) regardless race, blood specimen or co-i…

A Katsounas, M Trippler, EG Meissner, JF Schlaak, G Gerken, S Kottilil · Zeitschrift für Gastroenterologie · 2015 · Heft 01

Dokument
1175036
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Katsounas, M Trippler, EG Meissner, JF Schlaak, G Gerken, S Kottilil
Ausgabe
Heft 01 / 2015
Seiten
–
Erschienen: 2015-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0034-1397069

Zusammenfassung

Background: The LOX gene encodes a member of the lysyl-oxidase (LOX) gene family, which is involved in biogenesis of connective tissue, and 4 LOX-like proteins (LOXL1 – 4) have been identified so far. This study was aimed to investigate gene expression of LOXL1 – 4 in association with fibrogenesis in Hepatitis C Virus (HCV) infected patients with and without co-infection with the Human Immundeficiency Virus (HIV) in peripheral blood mononuclear cells (PBMC), peripheral whole blood (PwB) and liver tissue (LT) samples. Materials and Methods: PwB samples from 34 therapy-naive patients (34/34 Caucasians, 18/34 males…

Schlagworte

Association Blood Hepatitis African Americans Connective Tissue Germany ANOVA Zeitschrift für Gastroenterologie