A common FUT2 variant correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis
A Wannhoff, T Folseraas, M Brune, C Rupp, K Friedrich, J Knierim, KH Weiss, C Flechtenmacher, P Schirmacher, W Stremmel, JR Hov, DN Gotthardt · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Primary sclerosing cholangitis (PSC) can be complicated by the development of biliary malignancy as cholangiocarcinoma (CCA) and gallbladder carcinoma (GBCA). Besides the most commonly used serum screening parameter, namely CA19 – 9, screening with serum levels of carcinoembryonic antigen (CEA) is less examined. We thus conducted a study to investigate carcinoembryonic antigen (CEA) as a screening parameter for biliary malignancy in PSC patients. Based upon findings of a recent genome-wide association study that described an association between the genes of fucosyltransferases (FUT) and CEA, we thought to analyz…
