Inhibition of the transcriptional regulation of CDCA-induced BSEP expression by IL-1β involves the IL-1β triggered activation of autocrine chemokine circuits

* corresponding author Introduction: The liver as central regulator of multiple metabolic processes is indispensable for proper systemic function and survival. One important function is the synthesis and transport of bile acids for lipid digestion and adsorption. The malfunction of this machinery leads to accumulation of cytotoxic bile acids in hepatocytes and a subsequent severe damage of the liver. Modulation of transcriptional programs for bile acid homeostasis is achieved by activation of nuclear receptors such as the farnesoid X receptor (FXR), which plays a key role in bile synthesis, secretion, and detoxi…