Application of mathematical modelling to assess the functional importance of HIF1A for hepatoma biology

Liver cancer is becoming a major health problem in western societies due to constantly rising incidence and loss of effective long-term treatment options. HIF1A is frequently overexpressed in human cancers as well as murine tumor models and considered to be an attractive target for innovative cancer therapy. While hepatoma shows evidence for an activated hypoxic response, the functional importance of HIF1A for hepatoma biology remains largely elusive. Using mass spectrometry we have performed a detailed analysis of the tumor-specific proteome during hepatoma development in a murine model system (ASV-B). Protein…