Nup155 is involved in the posttranscriptional regulation of p53 target genes in HCC

The nuclear pore complex (NPC) consists of different subunits (nuclear basket and ring, spoke and cytoplasmic rings and the cytoplasmic filaments) the components of which are 30 specialized proteins called the nucleoporins (Nups). The NPC is embedded in the nuclear envelope and represents the only transport gate between the cytoplasm and the nucleoplasm. Therefore, it obtains a central role with almost all oncogenic and tumorsuppressive signal transduction cascades passing through it. An increasing body of evidence suggests that in addition to their role in transport some Nups can also modulate cancer-relevant p…