Proteasome subunit alpha type-6 regulates the expression of proviral host genes in hepatitis C virus infection
R Broering, M Trippler, M Lutterbeck, CI Real, DA Megger, T Bracht, V Schweinsberg, B Sitek, M Eisenacher, HE Meyer, HA Baba, AC Hoffmann, F Weber, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Objective: The interferon stimulated gene 15 (ISG15) plays an important role in the pathogenesis of hepatitis C virus (HCV) infection. ISG15-regulated proteins have previously been identified that putatively affect this proviral interaction. The present observational study aimed to elucidate the relation between ISG15 and these host factors during HCV infection. Design: Transcriptomic and proteomic analyses were performed using liver samples of HCV-infected (n= 54), HBV-infected patients (n= 23) and uninfected controls (n= 10). Primary human hepatocytes (PHH) were treated with toll-like receptor ligands, interfe…
