Preeclampsia – a risk factor for osteoporosis? – Analysis of maternal sclerostin levels and markers of bone turnover in patients with preeclampsia

Introduction: The role of preeclampsia in affecting bone metabolism could not be clarified in the past years. Recently sclerostin, a new marker of bone metabolism which is known to have an inhibitory effect on bone formation causing osteoporosis, was discovered. Objective: To investigate serum levels of sclerostin and markers of bone turnover in women with normotensive pregnancies and pregnancies complicated by preeclampsia (PE). Methods: In this prospective study we enrolled 22 women with preeclampsia and 22 healthy pregnant women to observe serum levels of carboxyterminal propeptide of type I collagen (PICP),…