Newly diagnosed type 1 diabetes patients exhibit lower hepatic ATP concentrations despite normal hepatocellular lipid accumulation
S Gancheva, A Bierwagen, P Begovatz, J Lundbom, P Nowotny, G Giani, B Hoffmann, J Szendroedi, M Roden · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background and aims: Nonobese patients with type 1 diabetes (T1D) can exhibit insulin resistance and have lower flux through muscular ATP synthase. Here, we examined the role of insulin resistance and hyperglycemia for hepatic energy metabolism in T1D. Methods: Forty-six newly diagnosed T1D patients (age: 33.8 ± 9.3 years; body mass index (BMI): 25.0 ± 3.7 kg/m2) with known diabetes duration of less than one year underwent euglycemic-hyperinsulinemic clamps to assess whole-body (M-value) and hepatic insulin sensitivity (insulin-mediated suppression of endogenous glucose production). Hepatic fat content (HCL), γ-…
