Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model
M Freichel, D Schumacher, C Matka, I Mathar, U Kriebs, R Sachdeva, P Stettner, HP Hammes, HJ Gröne, P Nawroth, T Fleming · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
The pathogenesis of hyperglycemia-dependent diabetic longterm complications involves the accumulation of reactive metabolites which were recently shown to affect cation channels such as Nav1.8 and TRPA1 channels as targets and essential effector molecules in signaling pathways involved in the disease process. Likewise, other members of the TRP cation channel family including members of TRPC and TRPM family are regulated in their acitivity by reactive metabolites including reactive oxygen species (ROS). We performed a screening using several TRPC- and TRPM-deficient mouse lines to elucidate a causal relevance of…
