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Klk7 plays a role in body weight regulation, insulin sensitivity and glucose metabolism

A Kunath, M Kern, M Stumvoll, M Blüher, N Klöting · Diabetologie und Stoffwechsel · 2015 · Heft 04

Dokument
1175423
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
A Kunath, M Kern, M Stumvoll, M Blüher, N Klöting
Ausgabe
Heft 04 / 2015
Seiten
–
Erschienen: 2015-04-29 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0035-1549589

Zusammenfassung

Background: Previous studies showed that beneficial effects on glucose metabolism of vaspin are at least in part mediated through inhibition of the protease Kallikrein 7 (Klk7). Based on these findings, we investigated the physiological relevance of the Klk7-vaspin system in mice with a targeted whole-body disruption of Klk7 in vivo. Methods: We generated a whole-body Klk7 knockout mouse (Klk7-/-) and systematically characterized the consequences of Klk7 deficiency on body weight, fat mass, serum concentrations of leptin and parameters of glucose and lipid metabolism. Results: Klk7 deficiency causes significant…

Schlagworte

Glucose Weight Metabolism Controls Insulin Sensitivity Serum Leptin Significantly Lower Plays Regulation Diabetologie und Stoffwechsel