16S rRNA analysis reveals changes in the gut microbiome of diabetic rats

Beneficial symbionts residing in our gut have positive therapeutic effects on several metabolic disorders including diabetes. Oral administration of probiotic and prebiotic foods strengthen the beneficial symbiont populations in the gut and may prevent immune-mediated destruction of pancreatic β-cells. The present study was designed to elucidate the gut microbiome of diabetic rats supplemented with a Lactobacillus probiotic and a prebiotic cell-wall extract from Saccharomyces cerevisiae. Diabetes mellitus was induced in male albino Wistar rats with allaxon-monohydrate (150 mg/kg). The rats were fed chow maintena…