Effect of LDL-apheresis on the soluble form of Activated Leukocyte Cell Adhesion Molecule (ALCAM)
A Sulaj, R von Bauer, S Kopf, M Brune, M Mendler, PP Nawroth, T Fleming · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction/Background: Cardiovascular disease is the major cause of death in patients with diabetes and atherosclerosis is exacerbated under diabetes. Atherosclerosis is an inflammatory disorder in which several converging immune responses induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) functions as a pattern recognition receptor and its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the role of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]…