Influence of lifestyle-induced weight loss on bile acids, FGF19 and total GLP1 in individuals with metabolic syndrome
R Biemann, M Penner, K Biemann, HU Marschall, K Borucki, S Westphal, C Luley, J Schneider, B Isermann · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: Bile acids (BAs) were identified as powerful metabolic regulators and discussed to influence development of the metabolic syndrome (MetS). Moreover, the secretion of FGF19 and GLP1 is controlled by BA receptors TGR5 and FXR suggesting a feedback mechanism between BA homeostasis and metabolism. Hence, we investigated the relationship between individual endogenous BA levels and the metabolic parameters FGF19 and GLP1 following lifestyle-induced weight loss in individuals with MetS by a longitudinal study. Methods: 74 non-smoking men (45 – 55 yr) with MetS have been randomized to a telemonitored lifes…
