Loss of Response to TNF-α blockers is associated with Levels of Drug and Antidrug Antibodies in IBD patients

Introduction: Treatment in inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]) has improved due to biologics. However, a problem is loss of response (LOR) maybe due to the formation of antibodies against these biologics. Our aim was to investigate antibody response against standard biologics infliximab (IFX) and adalimumab (ADA) in adult and paediatric patients with IBD. Methods: We conducted a prospective, multi-center study assessing antibody levels in IBD patients with active disease by an enzyme-linked immunoassay (Immunodiagnostik AG, Bensheim, Germany) which is able to measu…