Sclerostin levels and changes in bone metabolism after bariatric surgery
C Muschitz, R Kocijan, C Marterer, A Rahbar Nia, H Resch, GK Muschitz, P Pietschmann · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Context: The role of sclerostin as a key regulator of bone formation, remains unknown after Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (SG). Objectives: Evaluation of sclerostin and Dickkopf-1 (Dkk-1) serum levels after surgery and correlations with bone turnover markers (P1NP, CTX), parathyroid hormone (iPTH) and areal bone Mineral density (BMD) changes at total body, lumbar spine and total hip. Design and Setting: A prospective observational single-center two-arm study in premenopausal women with severe adipositas over 24 months. Participants: 52 premenopausal women (40 ± 8 years, BMI 4…