Modulation of claudin 8, 9 and 16 by interleucin 13 disturbs barrier function of upper airway epithelia

Introduction: Increased production of interleucin 13 (IL-13) is characteristically found in allergic asthma patients. Sensibilization to allergens as well as viral and bacterial infections contribute to asthma pathogenesis and are major triggers for disease exazerbation. In this case, the airway epithelium forms the barrier against invasion of those allergens and pathogens into the interstitium. IL-13 has been shown to result in remodelling of airway epithelium by increasing the proliferation of mucus producing cells. However, little is known about the effect of IL-13 on barrier function so far. Methods: Primary…