CareLit Fachartikel

Alternative chloride channels in cystic fibrosis (CF): Functional characterization of SLC26A9 in stably-overexpressing FRT epithelial cells

JJ Salomon, S Spahn, X Wang, J Füllekrug, CA Bertrand, MA Mall · Pneumologie · 2015 · Heft 07

Dokument
1175721
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
JJ Salomon, S Spahn, X Wang, J Füllekrug, CA Bertrand, MA Mall
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-14 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1556599

Zusammenfassung

Introduction: In CF patients, an impaired Cl-/fluid secretion across airway epithelia causing airway surface dehydration and airway mucus obstruction is due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Previous in vivo results revealed that the epithelial chloride channel SLC26A9 is essential for preventing airway obstruction associated with IL13-induced airway inflammation. These results suggest that SLC26A9 may be a promising alternative Cl- channel in CF. We therefore generated and characterized a novel epithelial cell line with stable expression of SLC26A9 to study its…

Schlagworte

Chloride Cystic Fibrosis Transmembrane Conductance Regulator Airway Obstruction Chloride Channels Dehydration Pneumologie