Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species

Chronic obstructive pulmonary disease (COPD) is a common irreversible severe lung disease. It is characterized by airway inflammation and progressive destruction of lung tissue resulting in emphysema. COPD is therefore a main cause for mortality and morbidity worldwide. A major reason to develop COPD is cigarette smoking. Lipopolysaccharides are commonly used pro-inflammatory model compounds but can not entirely reflect cigarette smoke features of COPD. The aim of the study is to establish a model of COPD in Precision-Cut Lung Slices (PCLS) of different species, including human, using cigarette smoke (Cs) and ci…