CareLit Fachartikel

β-NAD inhibits ATP-mediated interleukin-1β release

S Hiller, A Zakrzewicz, S Wilker, I Jurastow, A Hecker, W Kummer, W Padberg, V Grau · Pneumologie · 2015 · Heft 07

Dokument
1175724
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Hiller, A Zakrzewicz, S Wilker, I Jurastow, A Hecker, W Kummer, W Padberg, V Grau
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-14 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1556629

Zusammenfassung

Introduction: Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine, which plays a central role in host defense. High systemic IL-1β levels, however, can result in life-threatening systemic inflammation and acute lung injury. Release of IL-1β is typically controlled by two consecutive danger signals. Lipopolysaccharide (LPS) can be the first signal inducing the synthesis of pro-IL-1β. Extracellular ATP is a prototypical second danger signal, which leads to inflammasome activation, cleavage of pro-IL-1β and release of mature IL-1β. β-Nicotinamide adenine dinucleotide (β-NAD) is a co-enzyme for redox reacti…

Schlagworte

Acute Lung Injury Acetylcholine Cytokine Adenine Lead Pneumologie