NUT Midline Carcinoma of the Thorax: Case Report and Review of the Literature

NUT (nuclear protein in testis) midline carcinomas are exceedingly rare neoplasms with specific molecular alterations and often have a devastating course, whereas correct diagnosis is of utmost importance. Known from the sinunasal region for years, the new 2015 WHO classification for the first time also refers to this entity in the thorax, i.e. the lungs and the mediastinum. However, yet available data on this entity are sparse and a comprehensive review of thoracic NUT midline carcinomas is lacking. Here, we report on a 31 years old female patient with an aggressively growing tumor, localized in the median line…