Impact of non-invasive prenatal Testing (NIPT) on invasive procedures in a tertiary referral center

Purpose: To investigate the influence of NIPT on the frequency of invasive procedures in a tertiary referral center. Methods: Retrospective data analysis was conducted on pregnancies that presented for first trimester screening and 2nd trimester anomaly scan during a 16 months period before and after the introduction of NIPT. Results: 2340 and respectively 2929 cases before and after introduction of NIPT were enrolled. Before the introduction of NIPT, 144 invasive procedures were performed following first trimester screening (93 amniocentesis, 51 chorionic villous samplings). After the introduction of NIPT, 110…