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Contribution of the interleukin-6-type cytokine Oncostatin M to the pathogenesis of non-alcoholic fatty liver disease

HM Hermanns, C Schäfer, S Walter, D Dorbath, C Mais, D Jahn, A Geier · Zeitschrift für Gastroenterologie · 2015 · Heft 09

Dokument
1175821
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
HM Hermanns, C Schäfer, S Walter, D Dorbath, C Mais, D Jahn, A Geier
Ausgabe
Heft 09 / 2015
Seiten
–
Erschienen: 2015-09-14 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0035-1558899

Zusammenfassung

Background: Oncostatin M is an IL-6 family cytokine released by activated monocytes/macrophages, neutrophils and dendritic cells in the early phase of inflammatory processes. Surprisingly, it has recently been shown to execute protective functions in high-fat diet-induced obesity and related metabolic disorders in mice. Its role in the development of non-alcoholic fatty liver disease (NAFLD) and in conjunction with hypercholesterolemia, however, has not been addressed so far. Methods: C57Bl/6, Osmr-/-, Ldlr-/- single knockout and Ldlr-/-, Osmr-/- double knockout mice were fed a high-fat diet for 12 weeks. Weight…

Schlagworte

Cytokine Cholesterol Obesity Diet Dendritic Cells Blood Glucose Blood After Zeitschrift für Gastroenterologie